Pachysandra Alkaloids. III. Structures of Pachysandrine-B, -C, and -D

Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.

Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR stud...

Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii.

[structure: see text] Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) eleva...

Urdamycins, new angucycline antibiotics from Streptomyces fradiae. III. The structures of urdamycins C and D.

In our recent report of structural studies of urdamycins B to Fx), we published partial structures of urdamycins C and D, the two largest molecules amongthe complexof angucycline antibiotics produced by Streptomyces fradiae (strain Tu 2717)2). Nowwe can complete both structures, which are represented by the formulae 1 (urdamycin C) and 2 (urdamycin D). After several unsuccessful attempts to obt...

Terminamines K-S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis.

Nine new pregnane alkaloids (1-9), together with eight known alkaloids (10-17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12...

( a ) Φ ( a , B ) Φ Φ ( B , C ) ( C , D )